European Journal of Biomedical and Pharmaceutical Sciences

INHIBITION OF GENOTOXICITY EFFECT FOR ANTHRACENE IN LYMPHOCYTE IN VITRO USING FILTRATE LACTOBACILLUS ACIDOPHILLUS

Hussein Ali Dawood*, ISmail Hussein Aziz and Muhammad A. Al-A’adhmi

ABSTRACT

This study was conducted to determine the ability filtrate (lactobacillus acidophilus) in the inhibition of the genotoxicity for anthracene on lymphocyte in vitro using cytogenetic analyses, which include tests (chromosomal aberration, mitotic index, micronuclei) The results showed that the filtrate lactobacillus acidophilus have no genotoxicity in lymphocyte compared to the negative control, While concentrations of anthracene showed that there are a significant differences at (P<0.01) with increasingly higher concentrations of anthracene. The Results showed that the treatment between filtrate lactobacillus acidophilus and anthracene reduce the proportion of chromosomal aberrations and reduce a significant decrease in micronucleus formation. Was the best treatment are influential Add filtrate with anthracene or before and least influential is to add a filtrate after anthracene.

Keywords: genotoxicity, lactobacillus acidophilus, anthracene.