European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF SERUM ZINC LEVEL BEFORE AND AFTER HEMODIALYSIS IN SUDANESE PATIENTS WITH CHRONIC KIDNEY DISEASE

Abdalroof A.*, Mohammed T. and Hamza E.

ABSTRACT

Background: Zinc (Zn) is an essential trace element which plays an important role in growth, cell division, metabolism of protein, carbohydrates, lipids, synthesis of nucleic acid and bone metabolism. hemodialysis (HD) patient had low serum zinc concentration previously investigated. The present study was aimed to investigate possible affect hemodialysis to decrease zinc concentration by investigating serum zinc levels before and after hemodialysis. Methodology: Serum samples of forty patients on hemodialysis were collected before and after hemodialysis sessions and zinc concentration measure by atomic absorption spectrophotometer. Results: Zinc levels were found decreased by (26%) after hemodialysis when compared to the levels before hemodialysis. Conclusion: Zinc concentrations decrease after hemodialysis due to mechanism of hemodialysis which depends on concentration gradient between blood and dialysis fluid. Zinc supplementation may be recommended in hemodialysis patients with zinc deficiency, also the addition of zinc to dialisat can help to recover the zinc deficiency.

Keywords: Zinc (Zn), Hemodialysis (HD), End stage renal disease, Chronic Kidney Disease (CKD).