European Journal of Biomedical and Pharmaceutical Sciences

ASSESSMENT OF SERUM TOTAL TESTOSTERONE LEVEL AND LIPID PROFILE AMONG SUDANESE MALES WITH TYPE TWO DIABETES MELLITUS IN KHARTOUM STATE- SUDAN.

Myada L. H. Alaraki, Elhashimi E. Hassan, Elmutuz H. I. Elssaig and Abdalla E. Ali*

ABSTRACT

Background: Testosterone plays a significant role in glucose homeostasis and lipid metabolism. The objective of the study was conducted to assess serum total Testosterone levels among Sudanese males with type two diabetes mellitus and comparison with apparently healthy control. Methods: Descriptive cross sectional study, Fifty males with type two diabetes mellitus were selected as a test group was compared with a control group apparently healthy 50 volunteers. The analysed variables were age, serum levels of total Testosterone, lipid profile estimated, BMI was measured. Results: There was a significant decrease in mean of serum levels of total Testosterone in males with type two diabetes mellitus (1.99± 1.29) while (3.47 ± 1.94) in control groups respectively (P<0.001). In this study the prevalence of low serum total testosterone was 66% in patients with type two diabetes mellitus. There was a significant increase in the mean of serum levels of total Testosterone in good glycemic controlled males (2.68 ± 1.43) while (1.67 ± 1.10) in non-glycemic controlled groups respectively (P=0.009). The results indicated significant correlations between serum total Testosterone with serum levels of Triglyceride, HDL cholesterol, and insignificant correlations between serum total Testosterone with serum levels of Cholesterol, LDL cholesterol. The results indicated a significant correlation between the mean of serum total Testosterone & the age in type two diabetic patients (P=0.037), also indicate insignificant correlation between the mean of serum total Testosterone & BMI. Conclusions: It concluded that, the serum total Testosterone levels are significantly altered in Sudanese males with type two diabetes mellitus.

Keywords: Testosterone, lipid profile, HbA1c, Sudanese males, Diabetes Mellitus.