European Journal of Biomedical and Pharmaceutical Sciences

ANTICANCER STUDIES OF NOVEL 2-IODO -4-HYDROXYMETHYL -1, 5 - DIPHENYL SUBSTITUTED-1-H-IMIDAZOLE DERIVATIVES.

R. D. Bendgude* and M. S. Kondawar

ABSTRACT

The aim of the present study was the evaluation for anticancer activity of 2-iodo 4-hydroxy methyl- 1, 5 diphenyl substituted 1 -H- imidazole derivatives(C-IVa-j). Then identification of novel anti-cancer agents that can potently target cancer cells. Cancer is one of the major causes of death worldwide irrespective of the sex. The imidazole nucleus in general and its chemistry has Attention due to outstanding biological activities. In the present reports synthesized series of novel derivatives 2-iodo 4-hydroxy methyl 1, 5 diphenyl substituted 1 -H- imidazole derivatives(C-IVa-j ) and evaluated for their in vitro cytotoxic effects against MDA MB 4355 (Human breast cancer cell), by the MTT assay. The results were compared with the standard drug inhibitors 5 fluorouracil (10μg/ml). Compound no. C-IVc (41.00), C-IVf (49.72)and C-IVg(57.18) exhibited significant inhibitory activities against MDA MB 4355 (breast cancer) cancer cell lines at 20μg /mL concentration compared to the positive control 5-FU (54.33%) respectively. The results indicated that Compounds containing diphenyl substitution with, 4-Br, 3-OH, 2-NO2 and 2,4-dinitro showed potent anti cancer activity.

Keywords: Imidazole, Anticancer, Human breast cancer cell, MTT assay.