Abstract
ANTICANCER STUDIES OF NOVEL 2-IODO -4-HYDROXYMETHYL -1, 5 - DIPHENYL SUBSTITUTED-1-H-IMIDAZOLE DERIVATIVES.

R. D. Bendgude* and M. S. Kondawar

ABSTRACT

The aim of the present study was the evaluation for anticancer activity of 2-iodo 4-hydroxy methyl- 1, 5 diphenyl substituted 1 -H- imidazole derivatives(C-IVa-j). Then identification of novel anti-cancer agents that can potently target cancer cells. Cancer is one of the major causes of death worldwide irrespective of the sex. The imidazole nucleus in general and its chemistry has Attention due to outstanding biological activities. In the present reports synthesized series of novel derivatives 2-iodo 4-hydroxy methyl 1, 5 diphenyl substituted 1 -H- imidazole derivatives(C-IVa-j ) and evaluated for their in vitro cytotoxic effects against MDA MB 4355 (Human breast cancer cell), by the MTT assay. The results were compared with the standard drug inhibitors 5 fluorouracil (10μg/ml). Compound no. C-IVc (41.00), C-IVf (49.72)and C-IVg(57.18) exhibited significant inhibitory activities against MDA MB 4355 (breast cancer) cancer cell lines at 20μg /mL concentration compared to the positive control 5-FU (54.33%) respectively. The results indicated that Compounds containing diphenyl substitution with, 4-Br, 3-OH, 2-NO2 and 2,4-dinitro showed potent anti cancer activity.

Keywords: Imidazole, Anticancer, Human breast cancer cell, MTT assay.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: APRIL ISSUE PUBLISHED

    APRIL 2024 Issue has been successfully launched on 1 APRIL 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT