European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF SOME NOVEL 1,3,4-OXADIAZOLE BASED 1,2,4-TRIAZOL-[3,4-b]-[1,3,4]-THIADIAZINES

Sri Venkateswarlu Rayudu*, Dipankar Karmakar and Pramod Kumar

ABSTRACT

In the present study, a novel series of (5-phenyl-[1,3,4]oxadiaol-2-yl)-(6-phenyl-7H-[1,2,4]triazol[3,4- b][1,3,4]thiadiazin-3-ylmethyl)-amine and its derivatives (6a-f) has been developed. These target compounds were achieved by choosing 5-phenyl-[1,3,4]oxadiazol-2-ylamine (1) as raw material and by involving (5-phenyl- [1,3,4]oxadiazol-2-ylamine)-acetic acid ester (2), (5-phenyl-[1,3,4]oxadiazol-2-ylamine)-acetic acid hydrazide (3), 5-[(5-phenyl-[1,3,4]oxadiazol-2-ylamine)-methyl]-[1,3,4]oxadiazole-2-thiol (4) and 4-amino-5-[(5-Phenyl- [1,3,4]oxadiazol-2-ylamine)-methyl]-4H-[1,2,4]triazole-3-thiol (5) as intermediates. The chemical structures of all these compounds have been estimated by IR, 1H & 13C NMR, mass spectral data and elemental analysis. Further, the title compounds were evaluated for their preliminary in vitro antifungal activity against some fungal strains.

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