EVALUATION OF NITRIC OXIDE, URIC ACID AND CREATININE LEVELS IN PRE-ECLAMPSIA
Shobith Shetty, Srinidhi*, Tirthal Rai, Ullal Harshini Devi and Shilpa Shetty
ABSTRACT
Introduction: Pre-eclampsia is one of the multisystem disorder of pregnancy characterised by high blood pressure and protein in the urine, it is associated with endothelial dysfunction. The aim of the present study was to investigate the relationship between serum and urinary nitric oxide (NO), serum Uric acid and serum and urinary creatinin status between preeclamptic patients and normal control. Materials and Method: This study involves 34 normal healthy pregnant subjects & 34 cases of preeclampsia aged between 20 to 35 years attending the Department of Obstretics & Gynecology AJIMS, Mangalore. About 5ml of blood and urine was collected from the subjects used for the biochemical estimations. Result: Serum NO concentrations in preeclamptic women were significantly higher when compared to normal pregnant women, whereas a significant decrease was observed in urine NO in preeclamptic woman. Serum uric acid levels increased in preeclampsia patients when compared to normal individuals. Creatinine levels increased in preeclampsia patients in both serum and urine. Conclusion: This study might help clinicians to have diagnostic significance for the prediction of severity of the disease. Further experimental and clinical studies are necessary to clarify the pathogenesis of preeclampsia.
Keywords: Preeclampsia, Nitric Oxide, Uric acid, creatinine.
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