Abstract
ROLE OF ARE2 AND ARE3 PROMOTER REGION OF PSA IN FEMALE BREAST CANCER PATIENTS

Pavithra Venkateshaiah, Sathisha Tumkur Gururaja, Kasturi Kondapalli*, Jeevan Amos Seelam, Nasreen Sulthana and KRS Sambasiva Roa

ABSTRACT

Direct sequencing analysis of ARE2 and ARE3 region of PSA gene in 50 patient and 50 age- matched control samples was carried out in the present study. The T>C substitution was found in both cases and controls with a varied percentage i.e., 53.4% and 46% controls. This indicates the change is a common polymorphism reported in ARE-2 region of the PSA gene in evaluated number of samples. According to the pilot study the DNA variation T>C may not be playing a role in breast cancer. Multiple numbers of insertions were reported in patient samples when compared to controls in ARE2 region, these sequence alterations were not present in control samples analysed. All these insertions were found in the amplicon ARE2 of patient samples (8%) which may impact the regulation of transcription of PSA gene from this region. Conversely, to validate the definitive role of ARE2 region affecting expression of PSA gene in breast cancer large sample size studies are needed. All the samples analysed for ARE3 region did not report any DNA sequence changes in controls as well as cases indicative of its insignificant role in breast cancer.

Keywords: Prostate Specific Antigen, Androgen Response Element, Gene Polymorphism, ARE2, ARE3, Breast Cancer.


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