European Journal of Biomedical and Pharmaceutical Sciences

ALIPHATIC AND STEROIDAL CONSTITUENTS FROM THE SEEDS OF CAESALPINIA BONDUCELLA L.

Prawez Alam, Mohammed Ali*, Showkat Rasool Mir and Kamran Javed Naquvi

ABSTRACT

Caesalpinia bonducella L. (Caesalpiniaceae) is found in India, Myanmar and Sri Lanka. Its seeds are used to treat colic, convulsions, edema, abdominal pain, fever, leprosy, malaria, menstrual complaints, pneumonia, skin diseases, pimples, hydrocele, orchitis, pulmonary tuberculosis and palsy. A methanol extract of the seeds of C. bonducella L. was concentrated and adsorbed on silica gel (60-120 mesh) for the preparation of a slurry. The dried slurry was chromatographed over silica gel column packed in petroleum ether. The column was eluted with petroleum ether, chloroform and methanol successively in order of increasing polarity to isolate four new phytoconstituents characterized as n-triacontan-7,13α-diol (1, triacontanyl diol), n-pentatetracontan-23β-ol (2, pentatetracontanyl alcohol), n-hexacos-15-en-1,5-olide (5, bonducelloide) and 21-hydroxystigmast-5-en-3β-ol- 3-O-β-D-glucopyronosyl-6'-octadec-9"-enoate (6, bunducsteroid) together with three known compounds stigmasterol (3), β-sitosterol (4) and β-sitosterol glucoside (7). The structures of all these phytoconstituents were elucidated on the basis of the spectral data analysis and chemical reactions.

Keywords: Caesalpinia bonducella, seeds, fatty acids, steroids, aliphatic lactone.