Abstract
CAPTURING THE STRUCTURAL VARIATION OF 1-PHOSPHOFRUCTOKINASE FROM DIFFERENT PATHOGENIC BACTERIA: AN IN SILICO APPROACH

Dr. Ayon Pal*

ABSTRACT

The enzyme phosphofructokinase (PFK) plays a vital role in the linear EMP glucose degradation pathway where it catalyzes an important rate determining step, the phosphorylation of fructose-6-phosphate to fructose-1,6- bisphosphate. In this study, a relative analysis of the PFK protein sequences and tertiary structures have been carried out from a few plant and human pathogenic eubacteria to capture how the amino acid compositional fluctuation has transpired into structural variation. Phylogenetic analysis of the PFK protein sequences was also carried out using Bayesian approach. Analysis of the protein sequence as well as the structural features of PFK from different pathogenic eubacterial species suggest that the enzyme has evolved in a polyphletic manner and has undergone variable evolutionary change. In terms of evolutionary change, the PFK enzyme of Staphylococcus aureus and Streptococcus pneumoniae was found to demonstrate the least amount of change. The PFK enzyme of Clostridium perfringens was found to be quite unique, both in terms of amino acid composition and structural features from the remaining eubacterial species considered in this study.

Keywords: Phosphofructokinase, protein modeling, RMSD, multiple sequence alignment, phylogenetics, Bayesian inference, structural alignment, pathogenic bacteria.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2024 Issue has been successfully launched on 1 MAY 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT