Abstract
ABERRANT LINE-1 METHYLATION UPON HELICOBACTER PYLORI INFECTION

Mohammed Fawzi*, Zahra M. Al-khafaji, Sabah N. Al-Thamir, Hayder O. Hashim, Mazin J. Mousa, Osamah T. Muslim

ABSTRACT

Four histo-examination patterns of gastric biopsies used to study global genomic methylation status upon Helicobacter pylori infections by using LINE-1(long interspersed nucleotide element-1). H. pylori detection protocol in 120 samples was done by 23S ribosomal RNA gene. significant association (p= 0.03) have been showed between H. pylori and carcinogenesis progression comprising normal gastritis, atrophic gastritis, intestinal metaplasia and gastric cancer, respectively. Methyl-specific PCR showed that the methylation status of LINE-1 was decrease during carcinogenesis progression (p=0.0179). Among 56 H. pylori infected cases 32(57.1%) were LINE-1 hypomethylated, and there is no significant association between H. pylori infection and LINE-1 hypomethylation during development of gastric cancer (p=0.26). The current study confirmed that H. pylori is causative agent of gastric cancer, but not directly by causes aberrant LINE-1 hypomethylation which linked to gastric cancer progression.

Keywords: Helicobacter pylori, LINE-1, hypomethylation, carcinogenesis.


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