European Journal of Biomedical and Pharmaceutical Sciences

FERRIC CARBOXY MALTOSE A SAFE AND EFFECTIVE ALTERNATIVE IN CORRECTING IRON DEFICIENCY ANEMIA PRIOR TO MAJOR ELECTIVE GYNECOLOGICAL SURGERIES

Dr. Suyajna D. Joshi and Dr. Sangamesh Mathapati*

ABSTRACT

Background: Preoperative anemia is a common and potentially serious hematological problem in elective surgery and increases the risk for peri operative red blood cell transfusion. Transfusion is associated with postoperative morbidity and mortality. Ferric carboxy maltose is a novel intravenous iron formulation promising intervention to reduce peri operative transfusion. Objective: To evaluate the efficacy and safety of Ferric carboxy maltose in subjects with iron deficiency anemia preoperatively in major gynecological surgeries. Materials and Methods: It is a single group interventional study.100 women requiring major gynecological surgeries with iron deficiency anemia were administered with single dose of 1000mg FCM after clinical and biochemical assessment. The subjects were reassessed between 7th days to 21st day of infusion. Side effects, compliance were noted. Results: There was statistically significant rise of both Hb and S. Ferritin (2.28gm% & 729.82 ng/ml). All the blood indices showed statistically significant improvement after the intervention. There was clinical improvement in the symptoms and signs after the intervention. No serious adverse events were noted. Conclusion: Ferric carboxy maltose is safe and effective alternative to blood transfusion for correcting iron deficiency anemia in a shorter duration prior to elective gynecological surgeries.

Keywords: Ferric carboxymaltose, Preoperative anaemia, Gynecological surgery, Blood transfusion.