European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF METFORMIN MOUTH DISSOLVING TABLETS – A REVIEW

Priyanka Devi?and Md. Semimul Akhtar

ABSTRACT

Mouth dissolving tablets used as an alternative of conventional oral dosage form to improve the patient compliance. Many patient groups, such as the elderly, children, mentally retarded, uncooperative or nauseated, have difficulty in swallowing conventional dosage forms, like tablets. Swallowing conventional tablets will be further hindered by conditions such as unavailability of water, allergic reactions and episodes of coughing. These problems can be solved by developing rapidly disintegrating and dissolving tablet dosage forms for oral administration, because they dissolve in saliva and does not require water for swallowing. Upon ingestion, the saliva serves to rapidly dissolve the dosage form. The popularity and usefulness of the formulation resulted in development of several mouth dissolving tablet technologies for preparation. This article provides a brief overview on the use of Metformin mouth dissolving tablets which recommended for the treatment of diabetes type II.Metformin HCL is a biguanide antihyperglycemic agent used for treating non-insulin dependent diabetes mellitus (NIDDM).It improves glycemic control by decreasing hepatic glucose production, decreaseing glucose absorption and increasing insulin mediated glucose uptake.

Keywords: Mouth dissolving tablets,Metformin HCL, NIDDM,Superdisintegrants,Diabetes mellitus,Hypoglycaemia,Insulin,SSG,Crosscarmellose sodium,Mannitol.