European Journal of Biomedical and Pharmaceutical Sciences

TOLL LIKE RECEPTORS ROLE IN DERMATOLOGY- A REVIEW ARTICLE

Dr. Geeta Kiran Arakkal, Dr. Sudha Vani Damarla, Dr. Harish Kumar Kasetty and Dr Sudha Rani Chintagunta

ABSTRACT

Toll-like receptors are a class of proteins that play a major role in the innate immune system which is the first line of defence. Toll receptors were identified first in the fruit fly Drosophila by Christiane Nüsslein-Volhard in the year 1985.[1] Toll is a German word, which means “fantastic.” The name “Toll-like receptors” in other species were derived from the similarity to Toll receptors identified in Drosophila flies.[2] Nearly 13 members of the Toll-like receptor families have been identified in human and mice out of which Toll-like receptors 1, 2, 4, 5, 6 and 11 are present on the cell surface and Toll-like receptor 3, 7, 8 and 9 are localized in the endosomal/lysosomal compartment.[3]

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