ASSESSMENT OF ANTI-ATHEROTHROMBOSIS EFFECT AND PHYTOCHEMICAL SCREENINGS OF ETHANOLIC EXTRACTS OF ALBIZIA CHINENSIS (OSBECK) MERR. BARK
Tasnuva Rubbiat, Md. Hasibul Quader Chowdhury, Md. Areeful Haque*, Mohammed Abu Sayeed and Surajit Barua
ABSTRACT
Atherothrombotic diseases such as cerebral or myocardial infarction
are serious consequences of the thrombus formed in blood vessels.
Drugs like thrombolytic agents are used to dissolve the formed clots in
the blood vessels. But these drugs have certain limitations which may
cause serious and sometimes fatal consequences. Herbal preparations
have been used as medication since ancient periods for the treatment of
diseases of several kinds. The aim of this study was to investigate
whether the crude ethanolic extracts of bark of Albizia chinensis (Osbeck) Merr. possess
thrombolytic activity or not and at the same time the extract was screened phytochemically to
find out the chemically active components by applying standard metdods. In the antiatherothrombosis
test, the crude extract exhibited 14.96% clot lysis as compared to the
standard, streptokinase (81.08%). Preliminary phytochemical screenings with the crude
extract revealed the presence of alkaloids, flavonoids, saponins, reducing sugars, tannins and
gums.
Keywords: anti-atherothrombosis, phytochemical screenings, Albizia chinensis barks, ethanolic extract.
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