European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF NEWER PYRAZOLE DERIVATIVES

Karumudi Bhavya Sai, Nagandla Durga Deepak*

ABSTRACT

Pyrazole is an important class of heterocyclic compound, has been shown to exhibit diverse biological and pharmacological activities such as anti-cancer, antioxidant, anti-inflammatory, antimicrobial, etc. In this study, a series of pyrazole derivatives have been synthesized. All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were tested for their analgesic and antiinflammatory activities. The compounds exhibited significant analgesic and antiinflammatory activities. These compounds can be further exploited to get the potent lead compounds. The detailed synthesis, analgesic and antiinflammatory screening of the new compounds are reported.

Keywords: Pyrazole, Diphenyl, analgesic and antiinflammatory activities.