COMPARISON OF EFFICACY OF BUDESONIDE/FORMOTEROL VERSES FLUTICASONE/FORMOTEROL IN THE TREATMENT OF BRONCHIAL ASTHMA
Abin Joseph*, Anil Babu, Binu Raj C. and Seethadevi B.
ABSTRACT
Background and Objectives: The present study was designed to compare fixed combination of budesonide plus formoterol, with the fixed combination fluticasone plus formoterol. Main objective was to find out the combination having more efficiency and least adverse reactions Methods: This was a prospective observational study done for 9 months. Total number of patients participated in this study was 85. Out of this 44 patients were treated with budesonide/formoterol (400/6) and 41 patients were treated with fluticasone/formoterol (250/6). Baseline was measured at the time of admission as Forced expiratory volume in 1st second & Peak expiratory flow rate. Review of patients was done after 10 days. Results & Discussion: A significant improvement of lung functions from baseline was observed in both groups at all time point. Budesonide/ formoterol showed more improvement in lung function than fluticasone/ formoterol. Budesonide/formoterol showed 2.14L/min increase in peak expiratory flow rate and 1.1% increase in FEV1 than that of fluticasone/ formoterol. Also FEV1 in liter had an increase of 0.04L than fluticasone/ formoterol. Conclusion: The combination budesonide/ formoterol had slightly increased efficacy than fluticasone/ formoterol. Tolerability was found to be similar for both combinations. But fluticasone/ formoterol is expensive than budesonide/ formoterol. Thus the budesonide/formoterol is more economical for the patients. It indirectly improves the patient adherence to the medication. Thus budesonide/ formoterol combination was found to be better for an asthma patient in terms of efficacy and cost.
Keywords: Asthma, Budesonide, Formoterol, Fluticasone, Inhaled corticosteroids in asthma.
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