Abstract
FTIR-ATR SPECTROSCOPY AS A DIAGNOSTIC TOOL IN HYPOTHYROIDISM INDUCED BY CARBIMAZOLE – A STUDY IN ANIMAL MODEL

Prabhakaran A.R., Saira Khatheeja*, Krishna Mohan S., Senthilkumar S., Selvanathan P. and Safiullah A.

ABSTRACT

Hypothyroidism known as underactive thyroid, is a condition wherein the thyroid gland doesn't produce enough thyroid hormone. It is metabolically inter-related and affect/damage multiple organs leading to various complications and early screening is advised to check the disorder through proper medications. Carbimozole (20 mgs/Kg body weight) was given to induce hypothyroidism in male wistar rats for 21 days. The hypothyroid status has been assessed by measuring T3,T4 and TSH in serum by ELISA method as well as by FTIR-ATR spectral analysis. In addition to this other biochemical components were also analyzed to correlate the hypothyroid status. Current study focused on concept of economic and timely screening of the hypothyroid disease condition adopting reliable method. FTIR spectroscopy is used as a diagnostic tool in detecting disease condition by analyzing the functional groups of the biomarker(s) of concerned diseases. The spectral bands (4000 - 450 cm -1) obtained from serum was characterized for different biomarkers to assess the diseases status which aid in complete screening to control and management the disease. The chemical bonding stretches reveals the nature of bio molecule levels in serum. The results obtained on control and experimental animals were showed statistically more significant. The spectral study gives an additional information about the molecular basis which help in the detection and severity of disease condition. The results obtained were also correlated with other standard methods for comparison.

Keywords: Hypothyroidism, Biomarkers, FTIR-ATR Spectroscopy, male wistar rats.


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