Abstract
EFFECTS OF METHANOL EXTRACT OF ACIOA BARTERI ON HEPATOCELLULAR DAMAGE AND LIPID PROFILE OF ALBINO RAT

Aloh,G.S., *Obeagu,Emmanuel Ifeanyi, Odo Christian Emeka,  Okpara,kingsley Ezechukwu, Ugwu Getrude Uzoma and Ononogbu, Chimmuanya .E.

ABSTRACT

Methanol extract of Acioa barteri was evaluated for hepatoprotection and lipid profile activities in rats. The plant Extract at (250 and 500mg/kg) showed a significant (P<0.05) hepatoprotective activity against chloroform and hexane induced hepatotoxicity as judged from the serum marker Enzymes and antioxidant levels in liver tissues. Chloroform and hexane induced a significant rise in Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Lipid Peroxidase (LPO), Triglyceride and total cholesterol with a reduction of total protein, Superoxide Dismutase (SOD), Catalase, Glutathione Peroxidase, VIT C and VIT E. Treatment of rats with different doses of plant extract (250 and 500mg/kg) significantly altered serum marker Enzymes (AST and ALT), antioxidant (MDA, GSH, CAT and VIT C) and Lipid profile (TAG) levels to near normal against the chloroform and Hexane induced treated rat, when compared with the controls.

Keywords: Methanol extract, Acioa barteri, hepatoprotection.


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