FORMULATION AND EVALUATION OF LIQUID FILL FORMULATIONS FOR SOFT GELS OF LOPINAVIR AND RITONAVIR
Jyothirmayee Devineni*, Vasumathi Rangani and Sravya Nunna
ABSTRACT
The present investigation includes preparation and evaluation of liquid fill formulations for soft gels using combination of anti-retro viral drugs of Lopinavir (LOPI) and Ritonavir (RIT), in order to improve its dissolution properties and thereby it’s bioavailability. Liquid fill formulations were prepared by using excipients like Poly ethylene glycol (PEG-400), Propylene glycol (PG), Dimethyl sulphoxide (DMSO), Poly vinyl pyrrolidine (PVPK-30) and Ethanol. The prepared formulations were evaluated for appearance, pH, drug content, in-vitro dissolution studies, viscosity and stability studies. The compatibility between the drug and excipients were determined by FTIR spectra. The drug content of the liquid fill formulations were found to be in the range of 97.53 to 99.60 for LOPI and 97.64 to 99.35 for RIT and viscosity was found to be in the range of 39-138cps The formulation containing PEG/PG/DMSO/Ethanol/SLS system showed better drug release compared to other formulations. Formulation F7 is having superior drug release (100% drug release in 3 min for LOPI and 4 min for RIT) when compared to formulations with PEG/PG/DMSO/Ethanol and PVPK-30 systems. Hence F7 was selected as optimized formulation. The stability studies were conducted for all the formulations for a period of 6 months at room temperature. From these studies it can be concluded that Lopinavir and Ritonavir liquid fill formulations showed superior in-vitro drug release when compared to Lopinavir and Ritonavir tablets.
Keywords: Anti-retro viral drugs, Liquid fill formulation, Soft gel, Lopinavir, Ritonavir, poly ethylene glycol-400.
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