HISTO-TOXIC EFFECTS OF THE DRUG POSTINOR®-2 ON THE LIVER OF FEMALE WISTAR RATS
Adigun M. S., Fasogbon S. A., *Ajileye A. B. and Arije B. S.
ABSTRACT
Aim: The purpose of carrying out this research work is to determine the histo-toxic effects of the drug Postinor®-2 on the liver of female wistar rats. Materials and Methods: A total number of twenty five (25) adult female wistar rats were acquired from the animal house of the college of medicine, Ambrose Alli University Ekpoma and were used for this research work. The female wistar rats were divided into five (5) groups of five (5) rats in each group. The female wistar rats in Groups I-V were orally treated with the dose of Postinor®-2 at different concentrations (1ml of 1.5mg/100ml; 2ml of 1.5mg/100ml; 3ml of 1.5mg/100ml; 4ml of 1.5mg/100ml) and group V which is the control group were only fed with their normal food and water. At the end of the experiment, the rats were sacrificed, the liver was harvested and histological processed, sectioned with a rotary microtome, stained with haematoxylin and eosin and were examined microscopically. Results and Discussions: Microscopic examination of the liver revealed vacoulation, necrosis of the hepatocytes. Inflammatory cells and presence of perinuclear hallow around the recorded hepatocyte. Conclusion: From these findings, it may be inferred that excess use of Postinor® is associated with cellular and tissue damage of the liver.
Keywords: Postinor®-2, Vacoulation, Necrosis, Perinuclear, Hepatocyte.
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