European Journal of Biomedical and Pharmaceutical Sciences

SELF EMULSIFYING DRUG DELIVERY SYSTEM: AN APPROACH TO IMPROVE ORAL BIOAVAILABILITY OF LIPOPHILIC DRUGS

Jatinkumar R. Panara* and Nishith K. Patel

ABSTRACT

Mostly about 35-40% molecules which are pharmaceutical active ingredients (API) having challenging issues regarding Solubility and found to be lipophilic in nature. Those kind of drugs (Lipophlic drugs) having no water solubility or poor solubility in water. Thus, to overcome this challenge now a day’s various strategies have been investigated to improve the solubility and oral bioavailability. Among various approach self emulsifying drug delivery system gained more consideration due to enhanced oral bioavailability enabling reduction in dose, improved dissolution rate, temporal profile for absorption window, also discriminating targeting of drug(s) toward specific absorption window in GIT, and protection of drug(s) from the hostile environment in gut. Formulation face up to stability to overcome it in future SEDDS formulation should developed like Solid-SEDDS by converting emulsion to solid using carrier excipients, Developed Formulation should be applicable for large scale/industrial manufacturing because of economically simple technique of improvement of oral bioavailability.

Keywords: Self emulsifying drug delivery system, Biopharmaceutical systems, Water insoluble drugs, Solubility enhancement.