ANTI-EPILEPTIC/ANTI-CONVULSIVE EFFECT OF OCIMUM BASILICUM SMOKE IN ALBINO RABBITS
Aloh,G.S., Obeagu,Emmanuel Ifeanyi, Odo Christian Emeka, Stella Ngozika, Okpara,kingsley Ezechukwu, Ugwu Getrude Uzoma and Abia, Kenneth Ugochukwu
ABSTRACT
The ethanol, chloroform and whole -leaf extracts of Ocimum basHicum were evaluated for their anti-epiletic/anti-convulsant effects on rabbits. Convulsion was induced in these animals with over -dosage of penicillin. They were exposed to the smokes of the different extracts as they were having convulsive feats. The concentrations of glucose, creatinine and calcium in their sera were measured spectrophotometrically before, during and after convulsion. The mean calculated concentrations in the control before during and after convulsion were glucose: 107.50 ± 46,70mg/dl, creatinine: 1.55 ± 2.19mg/dl, and calcium: 9.00 ± 5.66mg/dl respectively. The mean calculated concentrations in those exposed to chloroform extract smoke before, during and after convulsion were glucose: 57.90 ± 6.61mg/dl, creatinine: 3.13 ± 1.19mg/dl, and calcium: 11.70 ± 1.56mg/dl respectively. The mean calculated concentrations in those exposed to. ethanol extract smoke before, during and after convulsion were glucose: 63.67 ± 26.21 mg/dl, creatinine: 2.70 ± 0.70mg/dl and calcium: 11.67 ± 2.50mg/dl respectively. And the mean calculated concentrations in those exposed to whole -leaf extract smoke before, during and after convulsion were glucose: 84.40 ± 32.70mg/dl, creatinine: 3.10 ± 1.49mg/dl and calcium: 11.33 ± 3.25mg/dl respectively. The results showed that the individual extracts of Ocimum basilicum had low anti-epileptic/anti-' convulsive effects. The whole -leaf extract had a profound effect when the animals were exposed to its smoke. This suggests that the components of the extracts act in synergy to give the observed effect.
Keywords: Ocimum basilicum, whole -leaf extract, anti-epiletic/anti-convulsant effects on rabbits.
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