European Journal of Biomedical and Pharmaceutical Sciences

ASSESSMENT OF LIVER ENZYMES IN PATIENT DIAGNOSTIC WITH H. PYLORI IN KHARTOUM STATE.

Khadija El khidir Abdelrahim, Omer Balla Ibrahim* and Salma Ali Albasheer

ABSTRACT

Background: H. pylori is a type of germ which attack human gastrointestinal tract mainly stomach and liver leading to gastritis, liver damage and hence elevated liver enzyme. The aim of the study was to estimate the liver enzymes ALT, AST and GGT in Patient with H. pylori Methodology: A case control study conducted at Khartoum hospital, Sudan. The study included 50 patient with H. pylori and 50 healthy individuals. Both groups were age and gender matched. The serum enzymes levels were measured using Cobas integra 400. Results The mean AST in the patient and control were (18 IU/L ± 9.9) and (13 IU/L ± 6.1) respectively. The mean ALT in patient and control in patient were (15 IU/L ± 8) and (11 IU/L ± 5.8) respectively. The mean GGT in patient and control were (19 IU/L ± 5.3)IU/Land control (11 IU/L ± 4.9) respectively. Conclusion: There were significant increases in AST, ALT and GGT levels of patient when compared to the control level p.value were 0.04, 0.012 and 0.000 respectively.

Keywords: Helicobacter pylori, liver disease , liver enzymes.