EFFECT OF LOW CLEARANCE, DIALYSIS AND DRUGS AFTER TRANSPLANTATION ON TESTOSTERONE, CALCIUM, PHOSPHOROUS, ALBUMIN AND ALKALINE PHOSPHATASE LEVELS IN SUDANESE MALE
Khalid Abdin Elhadi, Nada Mahmoud Altayeb and Mariam Abbas Ibrahim*
ABSTRACT
As many as 50 to 70% of CKD men have been reported to be hypogonadal on the basis of low concentrations of total and free testosterone. Beside disturbance of minerals and Albumin and Alkaline phosohatase in renal diseases which known as “kidney bone disease”, Renal osteodystrophy has been classically described to be the result by the damaged kidney. The present study aimed to evolution the effect of low clearance, dialysis and drugs after transplantation on testosterone, calcium, phosphorous, albumin and alkaline phosphatase levels in Sudanese male. 250 individuals male were included divided as follow 50 had low clearance, 50 in dialysis stage,50 functional renal transplant treated with Tacrolimus (prograf), 50 functional renal transplant treated with cyclosporine and 50 individuals apparently healthy as control group (mean age 45±15 years in all groups). Our finding showed significant decrease testosterone and calcium levels in all cases groups than in control group. The phosphorus levels showed significant decrease in transplant groups and significant increase in low clearance and dialysis groups compared with control, while Albumin levels were significant low in all cases groups except in low clearance group. Also we found negative correlation of testosterone with age and negative correlation of albumin with duration of renal impairment. In conclusion that all groups of renal diseases have low or low-normal levels of testosterone with hypocalcaemia while phosphorus level was increased in low clearance, dialysis and decreased after functional renal transplantation which indicate for sexual dysfunction and bone disease is more suggested in renal diseases patients.
Keywords: low clearance, Dialysis, Testosterone, Drug after Transplantation, Sudanese Male.
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