ANTICOAGULANT AND HYPOTENSIVE ACTION OF SALIVARY GLAND SECRETION OF ORNITHODOROS TARTAKOVSKYI AND HYALOMMA ASIATICUM MITES
*A. U. Mirzayeva, S. Kh. Umrqulova and F. D. Akramova
ABSTRACT
The scientists studied the anticoagulant actions of secretion from the salivary glands of ticks Ornithodoros tartakovskyi Olenev, 1931. and recorded the retardation of blood plasma coagulation in rats and sheep. Coagulation parameters depended on the concentration of secretion being tested (from 25 to 150μg/ml). At a maximum concentration (150μg/ml) the blood plasma coagulation rate (comparing with the test) drops to 79.7±5.6%. To determine the anticoagulant mechanisms of blood plasma with the deficiency of factors X, XI, IX & VIII the activated partial thromboplastin time was used. The platelet aggregation process was prolonged considerably in the test. The scientists also determined the role the ions [Ca2+] play in the regulation of the contractive activity of the smooth muscle cells in blood vessels, the process being directly connected with Ca2+. The researchers also determined the duration of the anticoagulant characteristics of blood plasma and the effect of the secretion concentration on the activity of the hemostasis system, which is very important for the medical and pharmacological areas. Part of this research was devoted to investigation of salivary glands’ extracts of ticks Hyalomma asiaticum on contractile activity of rat aorta. It was found that the extract has a strong relaxing effect on the aorta and modifies the properties of voltage-dependent calcium channels.
Keywords: Tick, Ornithodoros, salivary glands, anticoagulant, blood-vascular system, biologically active substances. Hyalomma, relaxant.
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