European Journal of Biomedical and Pharmaceutical Sciences

ASSESSMENT OF PLATELETS INDICES IN SUDANESE PATIENTS WITH DIABETES MELLITUS

Samah Obied Khalil and *Ibrahim K. Ibrahim

ABSTRACT

Background: Diabetic patients are at a high risk of developing micro and macro vascular diseases. Mean platelet volume (MPV) and platelet distribution width (PDW) are indicators of platelet function and activity and they have been reported to be influenced significantly by diabetes. The complications of diabetes mellitus are a leading cause of death in people with diabetes. Recent studies suggest that platelets count and indices with altered morphology could be associated with an increased risk for developing vascular complications in diabetes. Objective: To assess the Platelets count and Platelets indices in Sudanese Patients with diabetes mellitus. Method: This case control study was conducted in Omdurmanmedical clinic and hospitals in Khartoum state. A total of 50 Sudanese patients were diagnosed with diabetes mellitus type I and type II were included of his study and (50) apparently healthy non- Diabetic volunteered individual were used as controls, Patients included in this study werediabetes mellitus type I and type II. 2.5 ml of Venous blood of all Diabetic patients was collected in Ethylene Diamine Tetra acetic Acid (EDTA) containers to Complete blood count Platelet count and platelets indices (RDW, MPV,PCT) were measured by using Hematology Analyzer MINDRAY (280) made in china on the same day of collection, Clinical data were collected from patient medical records. Results: The mean platelet count for the Diabetic patients type I was (270.2917 ± 95) x 109/L; PDW was (12.31250 ± 0.3), the mean MPV (10.3 ±2.3) fL; the mean PCT was (0.25 ±.06%) for patients with type II mean platelet count for the Diabetic patients type I was (275.2917 ± 82) x 109/L; PDW was (14.3 ± 0.3) the mean MPV (15.5 ± .03) fL; the mean PCT was (0.25± 0.06%). Conclusions: Our study found higher platelet counts and MPV in Diabetic patients type II compared to type I Diabetic subjects.

Keywords: RDW, MPV, PCT.