European Journal of Biomedical and Pharmaceutical Sciences

STUDY OF PREDICTIVE FACTORS OF ANTI TUBERCULOSIS TREATMENT INDUCED HEPATOTOXICITY

Bijay Bartaula*, Bickram Pradhan, Narendra Bhatta, Naveen Kumar Pandey, Dharani Dhar Baral, Bandana Mudbhari

ABSTRACT

Tuberculosis is one of the commonest diseases prevalent in developing countries despite the availability of various chemotherapeutic agents for treatment. Combination chemotherapy is the basic mode of treatment, which may lead to various adverse effect of which hepatoxicity is one the commonest one. In this study we try to find the incidence of hepatoxicity and its predictors in all patients having tuberculosis and under anti tuberculosis treatment. Out of the 162 patients enrolled in our study, 34 patients (20.98%) developed drug induced hepatitis according to International Union against Tuberculosis and Lung Disease diagnostic criteria used for diagnosis of ATT induced hepatitis. Commonest clinical presentation of those developed drug induced hepatitis was Jaundice followed by anorexia, vomiting and nausea. In the study it is seen that low BMI, excess alcohol consumption and smoking is associated with ATT induced hepatitis. Identifying poor predictors and modifying the treatment regime prior the treatment of TB may decrease the chances of ATT induced hepatitis.

Keywords: ATT, Hepatitis, Combination chemotherapy.