IN VIVO EVALUATION OF ANTIDIABETIC PROPERTIES OF CAFFEIC ACID, SALVIANOLIC ACID AND VANADIUM PENTOXIDE IN SWISS ALBINO MICE
G. Rajalakshmi and R. Malathi*
ABSTRACT
Diabetes is the metabolic disorder which is classified into type 1 (in which body does not produce enough insulin) or type 2 (because cells do not respond to insulin that is produced). Type 2 diabetes has progressed beyond the point where it can simply be considered a medical problem and hence the present study was carried out to determine how the chosen compounds elicit anti diabetic response in Streptozotocin (STZ) induced Swiss albino mice. 36 animals were divided into six groups viz., control, STZ induced, STZ + positive control (glibenclamide) and treated groups of the three compounds (caffeic acid, salvianolic acid and vanadium pentoxide), with six animals in each group. Biochemical parameters were analysed and the results were interpreted for control and treated groups. STZ induced diabetic mice lowered the body weight of animals as they interrupted with the feeding of mice whereas the animals in treated group could lower blood glucose and help to gain body weight in animals injected with STZ. Caffeic acid has good potential to reduce blood sugar when compared to salvianolic acid and vanadium pentoxide.
Keywords: STZ, caffeic acid, blood glucose, serum cholesterol, salvianolic acid, vanadium pentoxide.
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