Abstract
FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLETS OF NEVIRAPINE

Swapna Neela*, Krishna Mohan Chinnala, Mamidwar Gajanand, Kondi Mounika and Motapalukula Amulya

ABSTRACT

Objective: The present research work was to formulate fast disintegrating tablets of Nevirapine. Methods: The formulation was developed with different concentrations of super disintegrants such as sodium starch glycolate, croscarmellose sodium and crosspovidone. Nevirapine fast disintegrating tablets were prepared by direct compression. All the ingredients were passed through 60# mesh sieve separately and collected. The drug weighed along with the other excipients and was mixed in geometrical order. This mixture was compressed using flat face 10mm oval shaped punch to get tablet of 500mg weight using tablet compression machine. Results: Fast disintegrating tablet showed a significant influence on disintegration and dissolution studies. Effect of super disintegrant on dispersion time and in vitro release has been studied. Fast disintegrating tablets containing crosspovidone showed excellent in vitro dispersion time and drug release as compared to other formulations. The cumulative % drug release profile of Fdt-6 formulation was found to be maximum when compared with other formulations. Conclusion: It is concluded that the formulated FDT tablets of Nevirapine using crosspovidone was capable of exhibiting immediate release properties. Among all the formulations Fdt 6 prepared with crosspovidone as disintegrant exhibited least disintegration time. As the concentration of superdisintegrant in the formulations increased the disintegration time was found to decrease. From the characterization of fast disintegrating tablets of Nevirapine it can be concluded that formulation containing crosspovidone is most acceptable. Fast disintegrating tablets of Nevirapine are a therapeutically effective, economical, commercially feasible approach for the therapeutic benefit of HIV patients.

Keywords: Fast disintegrating tablets, Nevirapine, Super disintegrants, Anti retroviral therapy.


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