European Journal of Biomedical and Pharmaceutical Sciences

NON ALCOHOLIC FATTY LIVER DISEASE IN DIABETES MELLITUS IN EASTERN NEPAL: A HOSPITAL BASED STUDY

Bhupendra Shah, Bickram Pradhan, Smriti Karki and Dharanidhar Baral

ABSTRACT

Non alcoholic liver disease (NAFLD) represents the most frequent liver disease in the world. Its prevalence is increasing due to its relation to worldwide obesity and type 2 diabetes. With increasing prevalence of Type 2 Diabetes and obesity, chances of increasing prevalence of NAFLD is high so timely identification of predictors of NAFLD will help us to screen, identify and manage such patient. We aim to identify the predictors of the non alcoholic liver disease in type 2 diabetes mellitus by comparing diabetes mellitus with NAFLD and without NAFLD. We conducted hospital based comparative cross sectional study on 170 patients of diabetes mellitus. Patient of Diabetes mellitus were compared based on NAFLD and non NAFLD status. Risk factors of NAFLD were assessed based on medical history, physical examination, laboratory assessments and imaging. The mean age of the study population in NAFLD was 54±12.2 years and non NAFLD was 57±12.7 year. Hypertension was significantly more common in patients with non alcoholic fatty liver disease (P<0.001). Patient with NAFLD had high body mass index (P<0.001), hip circumference (P<0.001) and waist circumference (P<0.001) than patient without NAFLD. Patient with nonalcoholic fatty liver disease had significantly higher fasting blood sugar (P-0.002), post prandial sugar (P<0.001), glycated haemoglobin (P<0.001), total cholesterol (P-0.001), trigyceride (P<0.001) and low density lipoprotein (P-0.009) and significantly lower high density lipoprotein(P-0.009). Smoking, obesity, hypertension, elevated blood sugar profile and dyslipidemia are risk factors for NAFLD.

Keywords: Non alcoholic fatty liver disease, Diabetes mellitus, Risk factors.