INTRAVENOUS IRON THERAPY IN PREGNANCY: A COMPARISON BETWEEN INTRAVENOUS FERRIC CARBOXYMALTOSE AND INTRAVENOUS IRON SUCROSE
Dr. Suyajna D. Joshi* and Dr.Chandana N.
ABSTRACT
Background: Anemia being the most common nutritional deficiency disorder in the world affects the pregnancy and its outcome, more so in the developing countries. With the prevalence of more than 60%in India, it needs an effective and novel tool for treatment of anemia in pregnancy which has deleterious effects on the mother and the baby. Ferric carboxymaltose formulation is safe and effective in treating iron deficiency anemia. Objective: To compare the safety, efficacy and tolerance of Ferric carboxymaltose and Iron sucrose in iron deficiency anemia in pregnancy. Methods: 100 pregnant women were allocated into two groups. Group A IV FCM group subjects were given 1000mg FCM at single setting. Group B IV Iron sucrose subjects were given multiple doses of 200mg per day on day 0,2,4,6,8 total of 1000mg iron sucrose. Both groups Hb%, PCV, Red cell indices, Peripheral smear were done on day 0 and after 4weeks of parenteral iron therapy. Rise in Hb, Red cell indices along with side effects and tolerability were noted. Results: There was statistically sifnificant rise in Hb (P<0.001)in FCM group of 2.09g/dl when compared to Hb in Iron sucrose group 1.82g/dl. No serious adverse effects were noted either in FCM group or Iron sucrose group. Conclusion: FCM can be used an effective alternative to afford the efficacy of IV Iron administration without the inconvenience of multile small doses, with less side effects and better tolerance in pregnancy.
Keywords: Anemia in pregnancy, Ferriccarboxymaltose, Iron sucrose, Iron deficiency.
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