MORPHOMETRIC CHARACTERISTICS OF NEURONS OF CEREBRAL CORTEX IN RATS UNDER ABDOMINAL AORTA NARROWING
*Havryshchuk Yu. M. and Herasymyuk I. Ye
ABSTRACT
The experiment, conducted on rats with abdominal aortic stenosis by means of light-optical microscopy and morphometric research methods, has shown that in the early period (up to 3 days of observation) there occur diverse morphofunctional reactions accompanied by subtotal or central chromatolysis in some neurons whereas in others this process is characterized by complete disorganization connected with the appearance of protoplasm hyperchromatism. These changes occurred at the background of paravasal and pericellular swelling. Moreover, it should be noted that the phenomenon of chromatolysis as well as paravasal swelling was more characteristic of layer III pyramidal neurons, and hyperchromatism was characteristic of layer V neurons of cerebral cortex in rats. Morphometric study helped to find out the increase of morphometric parameters in layer III neurons and the decrease in layer V neurons of the cerebral cortex in rats. On the 7th day of observation the stabilization of the detected changes was recorded, and then their reverse development was observed. However, the full restoration of the structure of neurons and their morphometric characteristics did not occur even after 28 days of observation.
Keywords: aortic stenosis, neurons, morphometry, swelling.
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