European Journal of Biomedical and Pharmaceutical Sciences

PHENYTOIN INDUCED JAUNDICE IN SEIZURES: A CASE REPORT IN PAEDIATRIC DEPARTMENT

Dr. B. K. Niranjan, Sai Theja G.*, P. Vineetha Varma, S. Arsiya Banu and M. Venkata Subbaiah

ABSTRACT

Phenytoin is a highly effective and widely prescribing anticonvulsant agent, but it can be associated with dose-related side effects like liver damage, jaundice, hepatocellular degeneration, megaloblastic anaemia. We found a case of phenytoin-induced jaundice in a 10-year-old male patient who had yellowish discoloration of eyes, an increase in bilirubin levels 9.5mg/dl, SGOT-1800 IU/lt, SGPT-1890 IU/lt, alkaline phosphate 373 IU/lt associated with vomitings for 3 days, abdominal distension for 1 day.15 days back patient had diagnosed as epileptic and prescribed with phenytoin 100 mg OD., but on evaluation we found that he took 100mg BID. So, this may be the reason for developing jaundice and the suspected ADR was Probable ADR (Naranjo’s scale). T. hepamerz 250mg BD is used to treat jaundice.

Keywords: SGPT (serum glutamic pyruvic transaminase), SGOT (serum glutamic oxaloacetic transaminase), LFT (liver function test), CBP (complete blood picture), Hb (hemoglobin), ALF (Acute liver failure).