European Journal of Biomedical and Pharmaceutical Sciences

EFFICACY OF NIGELLA SATIVA ON ALCOHOLIC GASTRITIS & GASTRIC ULCER

Fathima S.* and Kannan Eagappan

ABSTRACT

ABSTRACT The main objective of the study was to analyse efficacy of nigella sativa on Gastritis and Gastric ulcer by the oral administration route in mice. The efficacy of nigella sativa were studied simultaneously on blood biochemical parameter, enzymatic antioxidant, also on gastric histopathological parameters. The experiment design with thirty either sex albino wister rats weighing 150 – 200gms, were divided into five experimental groups and each group with six mice. Group –I (control without any treatment), Group – II (ethanol 70% orally), Group – III (Rantidine 30mg/kg body weight), Group – IV (Nigella sativa 250mg/kg orally), Group – V (Nigella Sativa 500mg/kg orally) respectively treated for 50 days. The alteration in histology of stomach, anti-ulcer activity, antioxidant, haematological changes among five groups were observed and recorded. A careful perusal of data evaluation revealed that the experimental group to which 250mg/Kg of the supplement exhibited significant decrease in gastritis, gastric ulcer in comparison to the standard group. The same result was also proved by histopathological examination of the gastric cells of the group of rats after the study period under consideration.

Keywords: Nigella sativa, Gastritis, Gastric ulcer, Histopathological.