Abstract
MnSOD GENE POLYMORPHISM INCREASE THE RISK OF NONALCOHOLIC FATTY LIVER DISEASE IN WEST INDIAN POPULATION

Dr. Hiteshkumar Vashrambhai Patel*, Dharti Keyur Patel, Dr. Nikhil Patel, Dr. Jatin D. Patel, Swetal Patel

ABSTRACT

Genetic predisposition plays a role in the pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD). Oxidative stress is major contributors in the pathogenesis of NAFLD. The aim of this study was to determine effects of MnSOD (Val16Ala) single nucleotide polymorphism (SNP) with the development NAFLD in West Indian population. 35 patients with NAFLD and 35 control subjects were enrolled matched according to age, gender and ethnicity. NAFLD was confirmed by ultrasonographic examination of the liver. Liver functions, blood glucose, serum insulin, lipid profile were assessed and HOMA-IR calculated. Genomic DNA was isolated form blood & Polymerase chain reaction- restriction fragment length polymorphism was used to determine SNP genotyping of MnSOD. In the present study BMI, ALT, AST, Fasting insulin, HOMO-IR, LDL-cholesterol, were significantly higher in patients with NAFLD than controls. The frequency of Val16Ala MnSOD polymorphisms in NAFLD patients was significantly higher in comparison with control subjects. The homozygous Ala/Ala genotype of the Val16Ala MnSOD was most frequent among patients with NAFLD (45.71%) as compared to control subject (8.57%). The highest Ala allele frequency was observed in the NAFLD patient group (61.43%) and this was statistically significant (p value < 0.001, OR = 0.23, 95% CI = 0.29- 0.68) compared to control healthy subjects (27.84%). These findings supported the idea that the Val16Ala MnSOD polymorphism contributes to the susceptibility to NAFLD in group of West Indian patients.

Keywords: NAFLD, MnSOD, Genetic polymorphism, Oxidative stress


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