Abstract
FORMULATION AND EVALUATION OF TRANSDERMAL CELECOXIB MATRIX PATCHES

Eskandar Moghimipour*and Binazir Baniahmad

ABSTRACT

Background: Celecoxib is a non-steroidal anti-inflammatory drug that has been used extensively to treat patients with arthritis. Its administration is limited due to its numerous disadvantages including gastric irritation and hepatic first pass metabolism. Objectives: The aim of the study was to prepare celecoxib containing transdermal patches to overcome all the mentioned disadvantages and to study the effect of polymers and plasticizer on transdermal release of the drug from patch formulations. Materials and Methods: Preparation of Celecoxib transdermal patches was carried out using various polymeric substances such as hydroxypropylmethyl cellulose (HPMC) and hydroxyethyl cellulose (HEC) and different plasticizers such as dibutylphthalate (DBP), glycerin (GLY) and propylene glycol (PG). The formulations were characterized using various physiochemical evaluation tests including moisture loss, content uniformity, weight variation, stability, drug release and tensile strength. Results and Discussion: According to the findings, transdermal patches containing celecoxib may produce acceptable systemic concentration which will achieve therapeutic effects of the drug and also shows fewer side effects.

Keywords: celecoxib, transdermal patches, polymer.


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