European Journal of Biomedical and Pharmaceutical Sciences

DIUERETIC ACTIVITY OF PLANT EXTRACT OF GARDEN SPURGE (EUPHORBIA HIRTA L.) ON MALE WISTAR RATS

Siti Nurjanah, Samsuar, Nopiyansah, Martha Lulus Lande and Mohammad Kanedi*

ABSTRACT

Because of its wide uses in many folk medicine system, the garden spurge (Euphorbia hirta L) is worth mentioning as a versatile herb plant. However, in relation to renal function, research results on the efficacy of these plants have not give a consistent result. This study, for that reason, aimed to reveal and verify the effect of ethanol extract of E. hirta against output of rat urine by using furosemide as a reference. Three different doses of whole plant extract of E. hirta (38.67, 77.35 and 154.7 mg/kg), furosemide (3.6 mg/kg) and distilled water (as negative control) were orally administered to the fasted healthy male rats. The urinary parameters assessed were the urine volume hourly for 6 hours, urine pH and urine color density. The results showed extract of E hirta at the dose of 77.35 mg/kg and 154.7 mg/kg significantly increase urine volume in comparison to the negative control but showed no difference with furosemide (α=0.05). However, all treatments showed no statistical difference in the urine pH and urine color scores. Thus, it can be conclude that the whole plant ethanolic extract of patikan kebo potentially for diuretic herb without make significant changes on pH and color of the urine output.

Keywords: Garden spurge, Patikan kebo, Euphorbia hirta, diuretic activity, urine pH, urine color.