STUDY OF CYTOTOXIC, THROMBOLYTIC AND ANTHELMINTIC ACTIVITY OF STEM OF CUSCUTA REFLEXA ROXB.
A.T.M. Mostafa Kamal*, Kazi Ashfak Ahmed Chowdhury, Azharul Islam ,Md. Masud Rana, Md. Ajmaoul Hossen Chy, Md. Moazzam Hossen Chy.
ABSTRACT
The study was aimed to evaluate the cytotoxic, thrombolytic and anthelmintic activity of methanol extract of the stem of Cuscuta reflexa Roxb. The cytotoxic activity of crude extract was determined using brine shrimp lethality bioassay and LC50 values of the sample was 181.134 ± 0.43 μg/ml whereas for standard vincristine sulphate was 8.50 ± 0.16μg/ml as a positive control. The extract showed (12.89 ±1.12%) clot lytic as compared to standard streptokinase’s (30.26 ±
0.67%) clot lytic activity in case of thrombolysis assay. The anthelmintic activity was done by using Tubifex tubifex by using three concentrations viz.,5, 8 and 10 mg/ml of the extract was studied which was mainly concerned with the determination of time of paralysis and time of death of the worms. The gradual increased in a dose exhibited, a gradual increase in the activity. The extract exhibited significant anthelmintic activity at highest concentration of 10 mg/ml as compared with levamisole (1 mg/ml) was evaluated as standard reference and distilled water as control.
Keywords: Cuscuta reflexa, Cytotoxic activity, Thrombolytic activity, anthelmintic activity Methanol extract.
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