Abstract
ASSESSMENT OF OXIDATIVE STRESS MARKER ENZYME SUPEROXIDE DISMUTASE(SOD) IN OSTEOARTHRITIS AND DIABETES PATIENTS AS A RISK FACTOR FOR URINARY INCONTINENCE.

Jubilee Hatai*, Sudip K. Banerjee, Apurba Ganguly, Sandip Bandopadhyay and Beauty Hatai

ABSTRACT

Background: Urinary incontinence is a condition that affects a significant proportion of the population. It is a common condition that can affect women and men of all ages with a wide variety of severity and nature. Different risk factors are associated with the development of urinary incontinence. Aim and Objectives: The aim of the present study was to assess the inhibition of oxidative stress marker Superoxide dismutase (SOD) in osteoarthritic and diabetic patients as a risk factor for urinary incontinence. Superoxide dismutase(SOD) is the antioxidant enzyme that catalyzes the dismutation of superoxide anion(O2_) into hydrogen peroxide and molecular oxygen. SOD plays an important protective role against cellular and histological damages that are produced by ROS. It facilitates the conversion of superoxide radicals into hydrogen peroxide, and in the presence of other enzymes it converted into oxygen and water. Materials and methods: The study protocol and all recruitment materials were approved by the ethical board.40 osteoarthritic patients, 40 diabetic patients and 20 controls were taken from OPTM Research Institute, 145 Rashbehari Avenue, Kolkata-700029, India. The oxidative stress marker superoxide dismutase was estimated in 40 arthritic, 40 diabetic and 20 controls. Results: The activity of SOD in control group and group I(osteoarthritic) were 27.86±3.98 and 24.39±6.51. When compaired between group I and control group, The level of SOD was significantly decreased in group I than control group and there was statistically significant lower SOD activity in group I as compaired with control group (p<0.05). The activity of SOD in control group and group II (diabetic) were 27.86±3.98 and 23.18±3.98.When compaired between group II and control group the level of SOD was also significantly decreased in group II than control group and there was statistically significant lower SOD activity in group II as compaired with control group (p<0.001).Conclusion: This study revealed that there was a decreased oxidative stress in osteoarthritic and diabetic patients and superoxide radical is inhibited by superoxide dismutase enzyme, decreases SOD activity in osteoarthritis and diabetes, as a risk factor for urinary incontinence.

Keywords: Urinary incontinence, Risk factors, Oxidative stress, Osteoarthritis, Diabetes, Superoxide dismutase (SOD).


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