COMPARISON OFMISOPROSTOL 25?G WITH DINOPROSTONE0.5MG FOR CERVICAL RIPENING FOR INDUCTION OF LABOUR
*Dr. Manjeet Nagra, Dr. Preet Kamal Bedi and Dr. Ashwani Kumar
ABSTRACT
The purpose of the study was to compare the efficacy and safety or 25μg misoprostol vs Dinoprostone0.5mg for the cervical ripening of the cervix at term. Nullipara of para one women the unfavourable cervices after 37 completed weeks with live foetuses were randomised to receive either 25μg intravaginal misoprostol or 0.5mg intracervical dinoprostone. The doses were repeated after 6 hours if the bishop score was less than 5. In case the cervical ripening does not reached after two doses of ripening agents, oxytocin induction was at least 6 hours apart. Induction delievery interval, pregnancy outcome and neonatal outcome associated with use of drugs were compared. 100 women – 50 in each group were evaluated. Comparatively more women with misoprostol(52.4% vs 35.6%) achieved cervical ripening after the first dose. The mean Induction delievery interval was significantly shorter in the misoprostol group. In the misoprostol group 94.7% were delivered within 24 hours as compared to 70% in the dinoprostone group. No significant difference found in the intrapartum complications and fetal outcome. A 25μg dose of misoprostol is superior in promoting cervical ripening, being cost effectivedo not need any temperature conditionsand easy to administer, significantly shortened the insertion delievery interval. It is safe and effective for cervical ripening.
Keywords: Tablet Misoprostol 25?g intravaginal, Dinoprostone gel 0.5mg intracervical, Cervical ripening, And Labour induction.
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