Abstract
AN EXPERIMENTAL STUDY TO EVALUATE THE ANTIDIABETIC EFFECT OF SYZYGIUM CUMINI LINN. SEED EXTRACT IN ALBINO RATS

Dr. Dick B. S. Brashier*, Dr. Sandeep Vihan and Dr. Htet Wai Moe

ABSTRACT

Diabetes mellitus is a chronic disorder causing considerable morbidity and mortality worldwide. Various herbs have been found to be useful in treating diabetes. Syzygium cumini Linn. Or Jamun tree is one such plant. Its extract has been identified as having antidiabetic properties. Present study was conducted with the aim of evaluating antidiabetic effects of aqueous extract of seed of Syzygium cumini Linn. in lab animals. This study was done employing normal euglycemic rats and alloxan induced diabetes in rats. Syzygium cumini Linn. Extract did not have any effect on the blood glucose levels of euglycemic rats either on acute or chronic administration. Syzygium cumini Linn Extract did not have any effect on ALT, AST, Serum bilirubin & creatinine levels in euglycemic rats. Syzygium cumini Linn extract, when given over 4 weeks, to alloxan induced diabetic rats, led to a dose dependent and time dependent reduction in blood glucose levels. Syzygium cumini Linn. extract did not have any effect on ALT, AST, Serum bilirubin & creatinine levels in alloxan induced diabetic rats. Syzygium cumini Linn. Extract has no effect on the blood glucose levels of euglycemic animals. Syzygium cumini Linn. Extract can reduce blood glucose levels in alloxan induced diabetic rats, in a dose dependent and time dependent manner. This study clearly demonstrates the efficacy of Syzygium cumini Linn. Extract in animal models of diabetes mellitus.

Keywords: Syzygium cumini, Aqueous extract, Antidiabetic activity, Albino rats.


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