European Journal of Biomedical and Pharmaceutical Sciences

COMPARISON OF ANALGESIC EFFICACY OF ANTICONVULSANT WITH ANALGESIC IN EXPERIMENTAL ACUTE AND BIPHASIC PAIN MODELS OF ALBINO RATS.

Ruchi Tyagi and Saurabh Kansal*

ABSTRACT

Some Antiepileptic drugs have been shown to be clinically efficacious in treatment of neuropathic pain and are being used by clinician. This study determined the analgesic effect of gabapentin (A novel Anticonvulsant) in rats in different types of acute and chronic nociceptive test like Tail flick and Formalin test & compared its potency with a conventional non opioid analgesic diclofenac. Per oral administration of gabapentin produced no any marked effect on early phase response of formalin test but significantly suppressed the late phase response. In tail flick test gabapentin produced no any significant analgesic effect while diclofenac produced significant reduction of pain in tail flick test as well as in both phases of formalin test. Thus we have observed that gabapentin produced antinociception in chronic pain as second phase of formalin test reflects chronic inflammatory pain while diclofenac produced both acute and chronic type of antinociceptive effect as it significantly suppressed the pain in both tail flick and formalin test.

Keywords: Gabapentin, diclofenac, nociception, formalin test, tailflick test.