HEPATOPROTECTIVE ACTIVITY OF METHANOLIC EXTRACT ON OPERCULINA TURPETHUM RHIZZOMS AGAINST CARBONTETRACHLORIDE INDUCED TOXICITY.
Kanakam Vijayabhaskar*, Sai Laxmi Mathukumalli and Kalakota Chaitanya Prasad
ABSTRACT
To study detailed Pharmacological evaluation for the methanolic extract of Operculina turpethum rhizomes at the dose of 200, 400mg/kg body weight per oral was studied for the hepatoprotective effect using Carbon tetrachloride induced liver damage in Wister albino rats. Methanolic extract showed significant (p<0.05) hepatoprotective effect by lowering the serum levels of various biochemical parameters such as serum glutamic oxaloacetate transaminase (SGOT), serum glutamic pyruvates transaminase (SGPT), alkaline phospatase (ALP), total bilirubin (TBL), total cholesterol (CHL) and by increasing the levels of total protein (TPTN) and albumin (ALB), in the selected model. These biochemical observations were in turn confirmed by histopathological examinations of liver sections and are comparable with the standard hepatoprotective drug Silymarin (100mg/kg body weight i.p.) which served as a positive control. The overall experimental results suggests that the biologically active phytoconstituents such as alkaloids, glycosides, tannins, flavonoids, sterols, fats, oils, phenols and saponins) present in them. The methanolic extract of plant Operculina turpethum rhizomes, may be responsible for the significant hepatoprotective activity and the results justify the use of Operculina turpethum rhizomes as a hepatoprotective agent.
Keywords: Operculina turpethum rhizomes, Hepatoprotective activity; Methanolic extract; Carbontetrachloride.
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