DAILY INTAKE OF FRUCTOLIGOSACCHARIDE REDUCES hs-CRP AND OTHER INFLAMMATORY MARKERS IN GRADE 1 SEDENTARY OBESE INDIVIDUALS RESIDING IN URBAN BARODA - A DOUBLE BLIND PLACEBO CONTROL TRIAL.
*Mini Sheth, Swati Parnami, Sania Quraishi, Jyoti Prakash, Anil Kumar, Manish Jain, Manoj Gote, Ashok Dubey
ABSTRACT
Background: Obesity is not an immediate lethal disease in itself but is a significant risk factor associated with a range of serious non-communicable diseases probably due to its association with inflammation of tissues of certain vital organs. Objective: To study the putative role of Fructooligosaccharide in modulation of Gut microflora and thereby affect the levels of inflammatory markers in obese individuals. Methodology: Using a double blind placebo control study design, eighty two sedentary obese subjects in the age group of 20-50 years who voluntarily agreed to participate in the study were purposively selected and were equally divided into two groups who received 10 ml liquid FOS and 10 ml liquid sucrose solution respectively for a period of 30 days. Their serum inflammatory markers in terms of TNF α, Leptin, and IL-6 was determined using Metabolic Hormone Magnetic Bead Panel and hs-CRP was determined using nephelometry method. Assessment of hematological indices was based on the principle of cell counting and volumetric analysis and the fecal bifidobacteria counts were determined using selective medium under anaerobic conditions. Results: Supplementation of liquid FOS significantly reduced the hs-CRP levels by 17.24% with a non-significant reduction in the TNF α, IL6 and Leptin levels was observed by 4.94% and 2.90% respectively. Conclusion: Daily intake of 10g of liquid FOS helps in reducing the low grade inflammation especially in terms of hs CRP and improved bifidobacteria colonisation in sedentary obese individuals and can be used as an effective strategy to delay obesity related co-morbidities.
Keywords: Fructooligosaccharide, bifidobacteria, Gut microflora.
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