Abstract
SYNTHESIS OF RU(II) THIOPHENE-IMIDAZO-PHENANTHROLINE POLYPYRIDYL COMPLEXES AND THEIR DNA BINDING, PHOTOCLEAVAGE, ANTIMICROBIAL AND CYTOTOXICITY ACTIVITY PROPERTIES

A. Dayanand, P. Venkat Reddy, Ch. Nagamani, Y. Praveen Kumar, M. Rajender Reddy, V. Ravi Kumar, K. Laxma Reddy and S. Satyanarayana*

ABSTRACT

Six octahedral Ru(II) polypyridyl complexes [Ru(phen)2NTIP]2+ (1), [Ru(bpy)2NTIP]2+ (2), [Ru(dmb)2NTIP]2+ (3), NTIP = 2-(4'-Nitrothiophene)imidazo[4,5-f][1,10]phenanthroline) [Ru(phen)2BTIP]2+ (4), [Ru(bpy)2BTIP]2+ (5), [Ru(dmb)2BTIP]2+ (6), BTIP = 2-(4'-Bromo thiophene)imidazo[4,5-f][1,10]phenanthroline; phen = 1,10-phenanthroline; bpy = 2,2'-bipyridine; dmb = 4,4'-dimethyl-2,2'-bipyridine; were synthesized and characterized by Elemental analysis, IR and NMR, Mass spectral methods. Absorption, emission, viscosity titrations were used to investigate the binding of Ru(II) complexes with calf thymus DNA and also investigated photocleavage of plasmid pBR322DNA. Molecular docking studies explored theoretical binding of these complexes. These complexes were assessed for their Antimicrobial and cytotoxic studies.

Keywords: Ru(II) complexes, Photoactivated cleavage, Docking, Antimicrobial and cytotoxicity.


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