European Journal of Biomedical and Pharmaceutical Sciences

COMPARISON OF PHENYTOIN AND VALPROATE FOR THE MANAGEMENT OF SEIZURES

Ishvar Parmar, Harsh Chapadia, Chaitanya Patel, Aditi Amin, Amr Atassi, Milisha Lal, Rono Korra, Bhargav Muppaneni, Kranthi Sunkara, Rumana Tokaria, Hitesh Talreja, Sapan Shah, Abhishek Vadher*

ABSTRACT

Aim: To compare the efficacy of Phenytoin and Valproate for the management of seizures. Methods: In this study, 50 patients were taken who were admitted to BJ medical in the department of Medicine from October 2013 to October 2015. We randomly selected 50 patients within the age >18 and were admitted to BJ medical for seizures. Inclusion criteria were seizures of any kind and age >18 years. Results: After 1 month, out of 32 patients started on Valproate, 18 patients (56.25%) had no seizures while 11 patients (34.37%) had 1-2 seizures and 3 patients had >2 seizures. Out of 18 patients started on Phenytoin, 9 patients (50%) had no seizures while 6 patients (33.33%) had 1-2 seizures and 3 patients (16.66%) had >2 seizures. The p value calculated was 0.741. After 12 months, out of 24 patients on Valproate, 4 patients (16.66%) had no seizures while 12 patients (50%) had 1-2 seizures and 8 patients (33.33%) had >2 seizures. Out of 11 patients on Phenytoin, 3 patients (27.27%) had no seizures while 5 patients (45.45%) had 1-2 seizure and 3 patients (27.27%) had >2 seizures. The p value calculated was 0.967. Conclusion: There is no difference in the efficacy of Phenytoin and Valproic Acid for the management of seizures.

Keywords: To compare the efficacy of Phenytoin Valproic Acid for the management of seizures.