Abstract
AN OVERVIEW ON MUCOADHESIVE DRUG DELIVERY SYSTEM

Sandeep S. Tate*, Ganesh V. Devkate, Sonali B. Deokate, Atul S. Bhujbal, Avinash P. Tupe, Dr. Rajendra N. Patil

ABSTRACT

Oral route is perhaps the most preferred to the patient and the clinician alike. However, per oral administration of drugs has disadvantages such as hepatic first pass metabolism and enzymatic degradation within the GI tract, that prohibit oral administration of certain classes of drugs especially peptides and proteins. Consequently, other absorptive mucosa is considered as potential sites for drug administration. Trans mucosal routes of drug delivery (i.e., the mucosal linings of the nasal, rectal, vaginal, ocular, and oral cavity) offer distinct advantages over per oral administration for systemic drug delivery. These advantages include possible bypass of first pass effect, avoidance of presystemic elimination within the GI tract, and, depending on the particular drug, a better enzymatic flora for drug absorption.

Keywords: Oral route, Trans mucosal routes, bypass of first pass


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