STUDIES ON EFFICACY OF MARINE BACTERIUM SALINICOCCUS ROSEUS PIGMENT FOR THEIR BIOACTIVE POTENTIAL
*G. Ramanathan and P. Ramalakshmi
ABSTRACT
The marineSalinicoccus roseus sourced from saltpan region of Mukkani, Tuiticorin District, has subjected for their ability to produce lycopene and which was used for the screening of anti-oxidant, anti cancer and anti-diabetic activity. The orange redcoloured colony produced on the Zobell marine agar medium indicates that the organism has ability to produce the pigment lycopene. The biochemical analysis and phylogenetic analysis showed that the strain was Salinicoccus roseus. An orange colour spot with Rf value of 0.41 observed for lycopene through thin layer chromatography. The UV- spectral analysis showed that the maximum absorption at 480nm which indicates the lycopene pigment. The HPLC analysis showed, the retention time at 2.88, it confirmed the lycopene pigment. The FTIR analysis revealed that the data for the functional groups of the lycopene pigment. Salinicoccus roseus lycopene pigment has better DPPH scavenging antioxidant activity with the IC50 value of 250µg/ml. Salinicoccus roseus also excert anticancer activity with the IC50 value of 250µg and only 47% cell viability was observed. Lycopene pigment extracted from Salinicoccus roseus has exerted better antidiabetic activity in invitro analysis, α-amylase inhibitory activity was noticed at higher concentration of lycopene pigment.
Keywords: : Salinicoccus roseus, Anticancer activity, Lycopene, Anti oxidant activity.
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