FORMULATION AND EVALUATION OF CARVEDILOL SOLID DISPERSION TABLETS FOR SOLUBILITY ENHANCEMENT
Arun Raj R.* and Dr. Jyoti Harindran
ABSTRACT
Objective: This study was mainly designed to solve the drawback of conventional Carvedilol solid dosage form, low bioavailability and limited clinical efficacy, by preparing Solid dispersion. Methods: Carvedilol solid dispersionwas developed by kneading method to modify the release and enhance solubility of the drug. The physical state of the dispersed Carvedilol in the polymer matrix was characterized by differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy, Fourier-transform infrared spectroscopy, super saturation solubility testing and dissolution studies. Optimized Carvedilol solid dispersions were formulated into tablets by direct compression method. Results: Compared with pure drug and physical mixture, the dissolution of Carvedilol - Solid dispersion was enhanced dramatically. Optimized Carvedilol solid dispersions tablet showed faster drug release in comparison to marketed tablet. Optimized formulation follows Higuchi’s equation and the release mechanism is super case II transport. Conclusion: The present study conclusively indicated that the use of solid dispersion method by using water soluble carriers improved the solubility of poorly water soluble drug.
Keywords: Solid dispersion, Carvedilol, Tablets, Optimization, Solubility enhancement.
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