European Journal of Biomedical and Pharmaceutical Sciences

ANTIDIABETIC ACTIVITY OF METHANOL EXTRACT OF Coriandrum sativum Linn FRUIT

M. Padmaa Paarakh

ABSTRACT

Diabetes mellitus is a metabolic disorder characterized by disturbances in carbohydrate, protein and lipid metabolism and by complications like micro vascular (retinopathy, neuropathy and nephropathy) and macro vascular (heart attack, stroke and peripheral vascular disease) complications. In the present study diabetes was induced in albino rat models with streptozotocine. Coriandrum sativum Linn, has been claimed to possess antidiabetic properties in Traditional System of Medicine. The present study was undertaken to screen the hypoglycemic activity of 75% methanol extract of fruits of Coriandrum sativum. The 75 % methanol extract showed significant decrease in blood glucose level at a dose of 100 mg/kg and 200 mg/kg. It also decreased the lipid parameters such as total cholesterol, total triglycerides, total bilirubin, SGOT,SGPT and SALP when compared with diabetic control. 75% methanol extract at 100 mg/kg was better in controlling diabetes when compared to 200 mg/kg bw suggesting that C.sativum to possess antidiabetic activity.

Keywords: Coriandrum sativum, Diabetes mellitus, Streptozotocine, Blood glucose, Lipid profile.